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Sierra Sciences
Sierra Sciences, LLC is a biotechnology company founded by William H. Andrews, former director of molecular biology at Geron Corporation. Andrews founded Sierra Sciences in 1999 in Reno, Nevada with the goal of preventing and/or reversing cellular senescence, and ultimately curing diseases associated with human aging, including the aging process itself.
==Background==
In humans, aging is strongly correlated with the length of an individual's telomeres, the repetitive DNA at the ends of each chromosome. Each time a cell in the body divides, its telomeres become shorter.〔 〕 Eventually, telomeres will shorten to the point where the cell is unable to divide (the "Hayflick limit"). The enzyme telomerase adds these DNA sequence repeats to the telomere, re-lengthening it. In humans, telomerase is expressed in embryonic stem cells and some other cells, but most somatic cells do not express it.
While working at Geron Corporation, Andrews co-discovered the RNA component of human telomerase ("hTR"), and was issued U.S. patent #5,583,016. For this discovery, Andrews was awarded second place as "National Inventor of the Year" in 1997 by the Intellectual Property Owners Association.〔 〕 Andrews also co-discovered the protein component of human telomerase ("hTERT"), for which he was issued U.S. patent #6,261,836. The hTERT gene is present in all human cells, but is repressed in most.
In 1997, Andrews left Geron, and, in 1999, founded Sierra Sciences to pursue the anti-aging implications of these discoveries, intending to find a drug that would "switch on" this repressed gene.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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